Holiday Inn Ames Conference Center is located approximately half a mile from the Hilton Coliseum, one mile from Ames Airport, and 45 miles from Des Moines Airport. The hotel is also half a mile from Jack Trice Stadium and the Reiman Gardens, three miles from Octagon Center for the Arts, and seven miles from Stagecoach Stables.

Hotel amenities include the indoor swimming pool, whirlpool, children's wading pool, fitness room, laundry facilities, free parking, and free weekday newspapers. In the morning, a complimentary continental breakfast is served, and complimentary appetizers are available Monday through Thursday nights in the bar.

All rooms have free high-speed Internet access, air-conditioning, clock radios, coffeemakers, interior access, dataports, voicemail, desks, hairdryers, irons and ironing boards, microwaves, refrigerators, and cable TV. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel. As of May 1, 2007, all guestrooms will be non-smoking. In order to continue to provide guests with a safe, comfortable, and enjoyable stay, Comfort Suites has adopted a 100% smoke-free environment