Radisson Plaza Santiago Hotel is located at the World Trade Center, one mile from San Cristobal Hill, and approximately 18 miles from Santiago International Airport. Santa Lucia Hill is eight miles, and Precolumbian Museum and Teatro Municipal are within ten miles of the hotel.

Hotel amenities include the Brick Restaurant, Traders Bar, lounge, coffee shop, 21st-floor health club (with views of the Andes), indoor swimming pool, hydro-massages, and sauna. The hotel also offers room service, a concierge, valet laundry service, babysitting, a gift shop, travel agency, beauty salon, vinery shop, and free parking.

All rooms feature working desks, two-line speakerphones, voicemail, Internet access, cable TV, in-room movies, coffee and coffeemakers, irons and ironing boards, minibars, safes, and bathroom amenities. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.