Marriott Prague is located within walking distance of the Old Town Square and approximately 14 miles from Prague International Airport. The hotel is also two miles from the Jewish Quarter and Charles Bridge, three miles from Prague Castle and Prague Zoo, and five miles from the Petrin House.

Hotel amenities include the swimming pool,solarium,gift shop, and 1,300-square-meter World Class Health Academy, which is located directly below the hotel and is free of charge for hotel guests. Meals and refreshments can be had at the hotel's Brasserie Praha (with a selection of cuisine from American, French, and typical Czech), the Lobby Bar, or through 24-hour room service. Other services include valet laundry, concierge services,complimentary coffee in the lobby and parking (at 17 euros per day).

Rooms feature high-speed Internet access, work desks, voicemail, dataports, cable TV, weekday newspaper delivery, minibars, bathrobes, irons and ironing boards, and hairdryers. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.