Overlooking the harbor, Holiday Inn St Thomas is within walking distance of duty-free shopping and the inter-island ferries and approximately two miles from Cyril King Airport. This location is also two miles from Griffith Ball Park and the Paradise Point Tramway and a short shuttle ride, provided by the hotel, to the beach on Magen's Bay.

Hotel amenities include the freshwater pool, mini-spa, beauty parlor, complimentary fitness center, dive shop, gift shop, Courtyard Lounge, and Windward Restaurant, serving continental and local West Indian cuisine. The hotel also offers room service, dry cleaning, laundry facilities, a concierge, free parking, and safety deposit.

All rooms feature high-speed Internet access, cable TV, in-room movies and video games, refrigerators, coffeemakers, safes, irons and ironing boards, hairdryers, voicemail, and individual climate control. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.