Holiday Inn Santee is located off Interstate 95, a mile from Santee Cooper Lake, and approximately 50 miles from Charleston International Airport. This location is also a mile from factory outlet shopping, two miles from the wildlife refuge, 15 miles from Eutaw Springs Battlefield, and 35 miles from Cypress Gardens.

Hotel amenities include the indoor swimming pool, whirlpool, fitness room, business center, cocktail lounge, and Kem's Restaurant. The hotel also offers room service, valet laundry service, laundry facilities, and parking. Small pets are welcome (prior approval and/or fees may apply).

All rooms feature satellite TV, in-room movies, refrigerators, coffeemakers, hairdryers, high-speed Internet access, free local calls, individual climate control, irons and ironing boards, voicemail, and work desks. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.