Holiday Inn Poplar Bluff is five miles from the Black River Coliseum and historic downtown Poplar Bluff and approximately 60 miles from Cape Girardeau Airport. This location is also two miles from John J Pershing VA Hospital, 10 miles from Current River, and 20 miles from Lake Wappapelo.

The property's amenities include the indoor swimming pool, whirlpool, 24-hour exercise room, business center, and Pasta House Italian Restaurant. The hotel also offers room service, self-service laundry facilities, valet laundry service, and free parking.

All rooms feature high-speed Internet access, cable TV, in-room movies, mini-refrigerators, coffee/tea facilities, individual climate control, irons and ironing boards, hairdryers, and free local calls. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.