Holiday Inn Express Wheeling is located approximately half a mile from Cabela's, 12 miles from Wheeling Downs Race Track/Casino, and 50 miles from Pittsburgh International Airport. This location is also six miles from the Kruger Street Toy and Train Museum, 11 miles from Oglebay Resort and Jamboree USA/Capital Music Hall, 12 miles from WV Independence Hall, 14 miles from Ohio Valley Mall, and 20 miles from the WV State Penitentiary.

The property's amenities include the fitness center, business center (with high-speed Internet access), and complimentary continental breakfast. The hotel also offers laundry facilities and free parking. Small pets are welcome (fee may apply).

All rooms feature cable TV, in-room movies, coffee/tea facilities, and hairdryers. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.