Holiday Inn Express Clarksville is located off Interstate 24, five miles from the Riverwalk (on Riverside Drive), and approximately 55 miles from Nashville International Airport. This location is also five miles from Dunbar Cave, six miles from Austin Peay State University, 20 miles from Collinsville, 35 miles from Opryland, and 36 miles from Oprymill Mall.

The property's amenities include the outdoor swimming pool, exercise room, and complimentary continental breakfast. The hotel also offers laundry facilities and free parking.

All rooms feature cable TV, in-room movies, high-speed Internet access, free local calls, dual-line phones, voicemail, microwaves, refrigerators, coffeemakers, air-conditioning, irons and ironing boards, and hairdryers. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.