Holiday Inn Express Chamberlain is located off Interstate 90, half a mile from the South Dakota Hall of Fame, and approximately 152 miles from Sioux Falls Joe Foss Field Airport. This location is also a quarter-mile from the Circle of Tee Pees, half a mile from Al's Oasis, two miles from the Missouri River, 15 miles from Big Bend Dam and Fort Thomson Casino, and 17 miles from Lower Brule Casino.

The property's amenities include the hot tub and complimentary continental breakfast. The hotel also offers free parking. Small pets are welcome (prior approval and/or fees may apply).

All rooms feature high-speed Internet access, cable TV, coffeemakers, dual-line phones, free local calls, voicemail, air-conditioning, irons and ironing boards, and hairdryers. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.