Holiday Inn Express Brenham is located approximately five miles from the Blue Bell Ice-Cream Factory and 80 miles from Bush Intercontinental Airport in Houston. This location is also 16 miles from Somerville Lake and the Antique Rose Emporium, 17 miles from Washington on Brazos State Park, and 85 miles from Austin Airport.

The property's amenities include the exercise room, sauna, outdoor pool, business center, and complimentary continental breakfast. The hotel also offers valet laundry service and free parking.

All rooms feature high-speed internet access, cable TV, in-room movies, coffeemakers, irons and ironing boards, and hairdryers. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.