Holiday Inn Express Antofagasta is located one mile from local beaches and Antofagasta Port and approximately 20 miles Cerro Moreno Airport. This location is also two miles from local shopping, 10 miles from Escondida Copper Mining Port, 60 miles from Hornitos Beach, 80 miles from El Abra Copper Mining, and 150 miles from Calama Airport.

The property's amenities include the outdoor swimming pool, whirlpool, exercise room, business center, cocktail lounge, and complimentary continental breakfast. The hotel also offers room service, a tour desk, self-service laundry facilities, and free parking.

All rooms feature high-speed Internet access, dual-line phones, free local calls, voicemail, work desks, cable TV, in-room movies, coffeemakers, individual climate control, safes, irons and ironing boards, and hairdryers. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.