Hilton Garden Inn San Diego Rancho Bernardo is off Interstate 15, near Rancho Bernardo Industrial Park, 24 miles north of downtown San Diego, and approximately 26 miles from San Diego International Airport. Corporations such as Sony, Hewlett Packard, Nokia, Seimens, Northrop Grummann, NCR, BAE Systems, and many more are located within minutes of Hilton Garden Inn San Diego/Rancho Bernardo. Wild Animal Park is 12 miles away and the San Diego Zoo, Sea World, and Lego Land are within 30 minutes. Downtown San Diego and beaches are about 20 minutes away.

Hotel amenities include the Great American Grill for breakfast, evening bar service, complimentary passes to a local 24 Hour Fitness, 24-hour Pavilion Pantry Convenience Mart, outdoor pool and whirlpool, complimentary 24-hour business and fitness centers, and complimentary weekday shuttle service within a five-mile radius of the hotel. The hotel also offers complimentary self-parking and complimentary high-speed Internet access.

All rooms feature work desks and ergonomic chairs, desk-level outlets, dual-line telephones, dataports, complimentary DSL Internet service, secure in-room printing to the business center, microwaves, coffeemakers, refrigerators, irons and ironing boards, hairdryers, and laundry services. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.