As the name implies, Days Inn Route 66 is located on Historic Route 66 in west Flagstaff. It is one mile from Flagstaff's historic downtown, featuring a variety of unique shops and fine dining establishments. There is easy access to I-40, I-17, highway 180, and highway 89. These roads lead to a variety of popular Arizona destinations such as Sedona, Grand Canyon, Walnut Canyon, Meteor Crater, Petrified Forest, The Painted Desert, and more.

If not relaxing by the lobby's fireplace, try relaxing in heated pool or lounge. A health club is a block away and the hotel offers five-dollar passes. Every morning, guests can enjoy a complimentary continental breakfast. The inn also offers ice/vending machines, 24-hour front desk, parking, safety deposit, laundry/valet services, and meeting facilities. Pets are allowed at a $10 fee per pet.

Each room has air-conditioning and cable television with pay movies and video games. Non-smoking and handicapped-accessible rooms are available. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.