Comfort Suites Prestonsburg is located in the foothills of the Appalachian Mountain Range, five miles from Dewey Lake, and approximately 135 miles from Blue Grass Airport. This location is also within walking distance of the Mountain Arts Center, half a mile from the Kentucky Opry, five miles from the Jenny Wiley State Resort Park and Jenny Wiley Theater, nine miles from Thunder Ridge Raceway, and 22 miles from Paintsville Lake.

The property's amenities include the fitness room, indoor heated pool and hot tub, and complimentary continental breakfast and day-long coffee. The inn also offers laundry facilities, free high-speed Internet access, and free weekday newspapers.

All rooms feature refrigerators, microwaves, coffeemakers, hairdryers, irons and ironing boards, free local calls, and cable TV. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel. As of May 1, 2007, all guestrooms will be non-smoking. In order to continue to provide guests with a safe, comfortable, and enjoyable stay, Comfort Suites has adopted a 100% smoke-free environment