Comfort Inn Buffalo is located at the crossroads of Interstate 90 and Interstate 25, blocks from historic downtown Buffalo, and approximately 35 miles from Sheridan County Airport. Lake DeSmet is about 10 miles away. Downtown Buffalo features historical buildings, specialty shops, and galleries. Also close to the hotel are parks, a large free summertime outdoor pool, a full-service YMCA, a highly-rated municipal golf course, and a walking trail along Clear Creek. A variety of restaurants are also in the surrounding area.

Hotel amenities include the whirlpool and complimentary continental breakfast. The hotel also offers cold weather hook-ups, parking, and free wireless high-speed Internet access. Small pets are allowed (fees or hotel approval may apply).

All rooms feature coffeemakers, hairdryers, irons and ironing boards, air-conditioning, and cable TV. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.